The paper regarding the new Niro NTF nozzle (patent pending) was presented
at the ILASS2004 conference in Nottingham UK. on September 8th. 2004 by Niels
Gottlieb and Christian Schwartzbach.
ILASS2004 is the 19th.
annual meeting of the institute of liquid atomization and spray systems
(Europe).
The NTF nozzle is an internal mixing two-fluid nozzle,
designed for pharmaceutical applications such as production of inhaleable
particles. The nozzle has a high capacity compared to existing two-fluid
nozzles still able to produce very fine droplets with a mean particle size
below 10 microns and a relative span of the droplet size distribution less than
2. The design is simple and easy to clean and inspect, specially designed to
meet the standards of pharmaceutical production.
Development of an Internal Mixing Two-Fluid Nozzle By Systematic
Variation of Internal Parts
- Written by Niels Gottlieb and Christian
Schwartzbach, Niro A/S Denmark.
ABSTRACT
Over the last few years Niro
A/S has investigated different types of commercially available two-fluid
nozzles. The investigation is motivated by the need for spray drying inhaleable
products with small particle size and narrow particle size distribution. The
test of different nozzles has led to modifications of existing nozzles and
later on to a new design of a two-fluid nozzle. The design criteria for the
nozzle are first of all a high liquid capacity and a high gas to liquid ratio,
necessary to obtain a small mean droplet size.
Droplet size
distribution is measured by laser diffraction equipment and the method used for
optimising the parts of the nozzle is empirical. The work has resulted in an
optimised internal mixing two-fluid nozzle with a narrow relative span of the
droplet size distribution and a minimised gas to liquid ratio (GLR). The
practical approach, described in this paper, has resulted in a short
development time, eliminating many practical obstacles already in the
experimental phase.
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