Production of dry sterile dosage forms often involves large-scale mixing of
the API with one or more excipients. To achieve a homogeneous mixture, the
particle size distribution of the excipient(s) must match that of the API. In a
one-step operation, spray drying can turn a sterile solution of the excipient
into sterile particles of the required size with no risk of introducing
impurities – a well-known problem if milling is used. Niro spray dryers for
sterile production are completely "tailor-made" for the task.